Overview of Picked Chemical Compounds and Intermediates
Overview of Picked Chemical Compounds and Intermediates
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one. Pharmaceutical Intermediates
Bortezomib Acid Impurity: This is often an impurity related to bortezomib, a proteasome inhibitor Employed in the remedy of several myeloma. Its synthesis or study is very important for guaranteeing the purity and safety of the drug.
Abiraterone Acetate Intermediate (CAS NO. 122111-01-seven): A precursor while in the synthesis of abiraterone acetate, a drug used in the procedure of prostate most cancers by inhibiting androgen manufacturing.
Imatinib Intermediate (CAS NO. 152460-ten-1): A vital compound from the synthesis of imatinib, a drug that targets certain kinds of most cancers, which includes Serious myelogenous leukemia (CML).
Docetaxel Intermediate: A compound Utilized in the synthesis of docetaxel, a chemotherapy medication that treats various cancers for example breast, lung, and prostate most cancers.
2. Chemical Impurities and Byproducts
GeMcitabine Intermediates (T6, T9, eight): These are generally intermediates inside the synthesis of gemcitabine, an anti-most cancers drug. Their research is essential for optimizing the generation approach and making sure substantial purity.
Lapatinib Intermediate (CAS NO. 231278-eighty four-5): Lapatinib is applied to deal with breast most cancers, and these intermediates are involved in its creation.
Fulvestrant Intermediates: Fulvestrant is definitely an estrogen receptor antagonist Employed in the treatment method of breast cancer. A variety of intermediates assist in N-Pyrazinylcarbonyl-L-phenylalanine the synthesis of the drug.
Paclitaxel Side Chain Acid (CAS NO. 949023-sixteen-nine): This intermediate is Utilized in the synthesis of paclitaxel, a chemotherapy drug effective in treating cancers such as ovarian, breast, and lung cancer.
three. Other Noteworthy Compounds
Irinotecan Hydrochloride Trihydrate (CAS NO. 136572-09-three): A chemotherapy drug used in the treatment method of colorectal most cancers and smaller cell lung cancer.
three-Amino-one-hydroxyadamantane (CAS 702-eighty two-nine): This compound is linked 5(10)-Triene-3 to the synthesis of adamantane derivatives, that have various programs, which include antiviral properties.
Vildagliptin Intermediates: Used in the production of vildagliptin, an oral drug for form two diabetic issues that inhibits the enzyme DPP-four to manage blood sugar stages.
4. Miscellaneous Compounds
D-Gluconic Acid δ-Lactone (CAS NO. 61259-48-1): This compound is associated with the synthesis of various gluconic acid derivatives, which might be Employed in food stuff, pharmaceutical, and industrial purposes.
Canagliflozin Intermediate two: A precursor inside the synthesis of canagliflozin, a medication utilised to handle style 2 diabetes by inhibiting sodium-glucose co-transporter 2 (SGLT2).